Inositol: give yourself a clean to support mood and hormonal activity


36172602_sInositol finds its major strength in its multiplicity of action, being one of the most important natural substances able at the same time to adjust metabolism, mental status and to guide liver detoxification.

Thinking of this substance – also known as mesoinosite or vitamin B7 – as a drug with a single specific action is totally wrong.

For years its use has been linked to detoxification, based on the important effects played at the level of mitochondrial efficiency. In other words, inositol improves oxygen consumption and correct functioning of those organs containing many mitochondria, such as muscles, liver and skin.

However, recent scientific research has described its action as “second messenger”, which results to be crucial in regulating many aspects of the metabolism.

As we have already reported, a “second messenger” helps passing on useful information, which can reach the cell internally. Inositol plays indeed this action (CH Tran et al, Front Physiol. 2014 Jun 30;5:243. doi: 10.3389/fphys.2014.00243. eCollection 2014), by acting as a very rapid conveyor of information that activates at least thirty of the most important enzymatic and metabolic functions of our organism.

This explains why the last few months have seen a series of scientific articles reporting novel possible beneficial effects of inositol integration.

A Japanese research group published a study in the Journal of Paediatrics Endocrinology & Metabolism highlighting how the increased consumption of inositol and its dispersion in urine may represent an indicator of diabetic tendency or at least of increased insulin resistance (Satake E et al, J Pediatr Endocrinol Metab. 2015 Sep 11. pious: /j/jpem.ahead-of- print/jpem-2015- 0107/jpem-2015-0107.xml. doi: 10.1515 / jpem-2015- 0107. [Epub ahead of print]).

A few days before that study, a group of gynaecologists from California had published a similar article on the journal Reproductive Sciences, pinpointing how inositol dysregulation during the first trimester of pregnancy may be correlated with a higher incidence of gestational diabetes (A Murphy et al, Reprod Sci. 2015 Sep 8. pii: 1933719115602767. [Epub ahead of print]).

Therefore, the relationship between inositol and sugar metabolism finds stronger confirmation, thus indicating its usefulness in supporting every case of insulin resistance.

Classically, the use of at least 2 grams of inositol (for example, 2 tablets of Zerotox Inositox) in the morning before breakfast, even for prolonged periods, contributes to improving polycystic ovary syndrome (together with specific hormonal regulation) and acne (two grams per day, even for long periods), either as an exclusive treatment or alongside other therapies used (antibiotics, contraceptive pill, retinoids).

Last June, a French study reported the improvement in insulin sensitivity in animal models after inositol administration, and also reported that its administration limited cell emptying, preventing events linked to diabetes (Croze ML et al, Br J Nutr. 2015 Jun 28; 113 (12): 1862-75. doi: 10.1017/S000711451500121X. Epub 2015 May 20).

That’s not all, since a group of American psychiatrists (University of Maryland School of Medicine, Baltimore) studied the same kind of problem (inositol depletion from brain cells) in relation to depression; the less inositol is contained in brain cells, the more likely it is to develop depression (Chiappelli J et al, Neuropsychopharmacology. 2015 Aug; 40(9): 2157-64. doi: 10.1038/npp.2015.57. Epub 2015 Feb. 27).

We know with certainty that inositol, through its energy regulating action, is able to naturally improve mood and have highly significant antidepressant effects.

Inositol integration (2 to 3 grams per day) can probably prevent inositol brain emptying and allows maintaining the mood tone on positive levels.

Therefore, the list of its positive actions is longer and longer. Inositol helps in:

  • Liver detoxification
  • Acne control
  • Modulation of polycystic ovary syndrome
  • Anti-depressive actions
  • Improved insulin sensitivity
  • Diabetic Prevention
  • Chemotherapy support
  • Hormonal regulation

Similarly to physical activity, inositol improves insulin sensitivity by activating glucose transport channels (GLUT4) needed to counteract the insulin resistance caused by numerous unhealthy dietary


Using inositol according to the prescribed instructions is like acting on the “carburation phase” of an engine (by using an example), regulating its inner workings in a fine and gentle way. This way, we can effectively regulate our body through fine, natural signals in a way not many drugs are able to offer.